immune system | Southern Fried Science

Fun Science FRIEDay – The Emperor of all Maladies

Posted on January 24, 2020 by Kersey Sturdivant

The Emperor of all Maladies is how Siddhartha Mukherjee, an Indian-born American physician and oncologist, aptly described cancer. Cancer, this scourge of mankind going back as far as 4,600 years ago when it was identified by the Egyptian physician Imhotep (the first in recorded history). Cancer takes one of the most successful traits of complex eukaryotes, cell division, and weaponizes it in unchecked cellular growth; some even consider cancer to be a more evolved form of cell division. This ailment has plagued humanity, and baffled physicians for centuries as they attempt to tackle the seemingly impossible, discover a cure for cancer.

Scanning electron micrograph of a human T cell. (NIAID/Flickr/CC BY 2.0)

Fun Science FRIEDay – Gut Enzyme Turns Blood Into Type O

Posted on November 16, 2018 by Kersey Sturdivant

The process of blood transfusions, started in the late 19th century and perfected in the early 20th century, were a big advancement in modern medicine and the treatment of human health. Part of the improvements in this procedure was the discovery of the various blood types in humans, and how that affects how the immune system responds to and “accepts” blood transfusions. Recently, researchers from the University of British Columbia may have found a reliable way to use a bacterial enzyme from the human gut to convert any type of blood into type O – which is compatible with nearly everyone.

Animation of red blood cells (Photo credit: meghanmecrazy)

Fun Science FRIEDay – Virus be good!

Posted on November 6, 2015 by Kersey Sturdivant

“The era of the oncolytic virus is… here.” Stephen Russell, Cancer researcher and haematologist at the Mayo Clinic in Rochester, Minnessota

…. and let me be the first to welcome our new virus overlords!

Viral-based cancer therapy: T cells (orange) are recruited to attack malignant cells (purple). (Photo credit: Dr. Andrejs Liepins/SPL)

Last week the US Food and Drug Administration (FDA) made a decision that received little fanfare, but has huge implications for modern medicine and how we approach cancer treatment in the US. That decision? The FDA granted their approval for a genetically engineered virus to be used to treat cancer. That virus was the herpesvirus called talimogene laherparepvec, and its use is for the treatment of melanoma lesions in the skin and lymph nodes. This huge decision makes it the first oncolytic virus to receive market approval and could pave the way for more oncolytic viruses to enter the “market.”