How anglerfish hack their immune system to hang on to a mate

This article originally appeared in the August/September 2020 issue of the Deep-sea Mining Observer. It is reprinted here with permission. For the latest news and analysis about the development of the deep-sea mining industry, subscribe to DSM Observer here: http://dsmobserver.com/subscribe/

When you live in the darkness of the abyss, finding a partner is hard and keeping a partner is even harder. Deep-sea anglerfish, one of the iconic ambassador species of the deep ocean, have found a novel solution to this problem–dwarf males are sexual parasites that latch onto the body of the much larger female anglerfish and then physically fuse to their partner, becoming permanently attached to the point where they share a circulatory and digestive system. 

Parasitic dwarf males are uncommon, but not unheard of, throughout the animal kingdom. Osedax, the deep sea bone eating worm, also maintains a harem of dwarf males in a specialized chamber in their trunk. But few species, and no other vertebrates, go to quite the extremes of the anglerfish. And with good reason. 

Vertebrate immune systems have a long shared history. The Major Histocompatibility Complex (MHC) is a suite of genes shared among all gnathostomes–the taxonomic group that contains all jawed vertebrates, from fish to fishermen. It creates the proteins which provide the foundation for the adaptive immune system, the core complex which allows bodies to tell self from no-self, detect pathogens, and reject non-self invaders. Suppressing the MHC seriously inhibits a vertebrate’s ability to fight off infection. 

Incidentally, not all deep-sea anglerfish have parasitic dwarf males, and the species most often presented as a type specimen in the popular press, the humpback anglerfish Melanocetus johnsonii, is one of several that do not have permanently attached parasitic dwarf males. M. johnsonii males are free-swimming throughout their life, they’re just small and clingy.

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Bioprospecting in Practice: How a drug goes from the ocean to the clinic.

This article originally appeared in the June/July 2020 issue of the Deep-sea Mining Observer. It is reprinted here with permission. For the latest news and analysis about the development of the deep-sea mining industry, subscribe to DSM Observer here: http://dsmobserver.com/subscribe/

Bioprospecting, the discovery of new pharmaceutical compounds, industrial chemicals, and novel genes from natural systems, is frequently cited among the critical non-mineral commercial activities that yield value from the deep ocean. Isolating new chemicals or molecular processes from nature can provide substantial benefits to numerous industries. The value of products derived from marine genetic resources alone is valued at $50 billion while a single enzyme isolated from a deep-sea hydrothermal vent used in ethanol production has an annual economic impact of $150 million. 

In contrast to other extractive processes, bioprospecting is driven by and dependent on biodiversity. The greater the diversity and novelty of an ecosystem, the greater the likelihood that new compounds exist within that community. Bioprospecting is also viewed as light extraction, compounds only need to be identified once–actual production happens synthetically in the lab–thus leaving ecosystems relatively undisturbed compared to more intensive industries.

Despite the promise and importance of bioprospecting, there is generally a relatively poor understanding of what the process of discovery entails. How do researchers go from sponges on the seafloor to new antiviral treatments? 

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Creating Healthy Working Cultures in Marine Science Education

Below you’ll find a document I’ve been thinking about for more than a decade. I teach marine science field skills to undergraduates and graduate students at Field School and the University of Miami, and I’ve had a lot of opportunities to observe science and scientific learning in action. This is my best effort to distill the key principles I’ve learned about creating a healthy, supportive working environment. Starting the year, my students at Field School will all read and sign on to these principles before working with us.

It feels important to add that cultures are the product of choices and actions (or inaction). They don’t create themselves; they are created by the people within them. That means, sadly, that in every toxic organization there are people who choose, and benefit (or think they benefit) from that toxicity. The good news is that it also means we can choose something else. It’s not out of our hands.     

I’ve spent a lot of my time thinking about how to create welcoming, supportive learning environments for all of my students. And no: I don’t believe compassion and acceptance mean you have to sacrifice scientific rigor—in fact, I think students learn and grow more in these settings.

If you are also engaged in looking for solutions to the systemic problems in how we train future marine scientists, please feel free to join me by sharing this, implementing it in your own teaching, or reaching out with suggestions for how it can be improved based on your knowledge and practice. If you are a student who is struggling with these issues and you need advice or a friendly ear, please know that you are not alone, and my inbox is always open to you.

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Fun Science FRIEDay – A fish without blood

Amidst all the hysteria surrounding the seemingly unstoppable COVID-19, we bring you a story of a fish without blood. In 1928 a biologist sampling off the coast of Antarctica pulled up an unusual fish. It was extremely pale (translucent in some parts), had large eyes and a long toothed snout, and somewhat resembled a crocodile (it was later named the “white crocodile fish). Unbeknownst at the time, but the biologist had just stumbled on a fish containing no red blood pigments (hemoglobin) and no red blood cells – he iron-rich protein such cells use to bind and ferry oxygen through the circulatory system from heart to lungs to tissues and back again. The fish was one of  sixteen species of what is now commonly referred to as icefishes that comprise the family Channichthyidae, endemic around the Antarctic continent.

The Antarctic ice fish on the seafloor surrounded by brittle stars. (Photo credit:  E Jorgensen/Alfred Wegener Institute)
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Fun Science FRIEDay – Suspended Animation

Scientists (and sci-fi fans) have to varying degrees been discussing the concept of suspended animation for years; the idea that the biological functions of the human body can somehow be put on “pause” for a prescribed period of time while preserving the physiological capabilities. If you’ve ever watched any sci-fi movie depicting interstellar travel you have probably seen some iteration of this concept as a way to get around the plot conundrum of the vastness of space and space travel times, relative to natural human aging and human life span. The basic principle of suspended animation already exists within the natural world, associated with the lethargic state of animals or plants that appear, over a period, to be dead but can then “wake-up” or prevail without suffering any apparent harm. This concept is often termed in different contexts: hibernation, dormancy, or anabiosis (this last terms refers to some aquatic invertebrates and plants in scarcity conditions). It is these real-world examples that likely inspire the human imagination of the possibilities for suspended human animation. The concept of suspended human animation is more commonly viewed through the lens of science fiction (and interstellar travel), however, the shift of this concept from scientific fiction to science reality has a more practical human application.

Computer artwork of futuristic humans in suspended animation (Photo credit: Science Photo Library).
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Probing the submerged caves of Bermuda with Trident

Dr. Blanco-Bercial pilots the Trident ROV in one of Bermuda’s submerged caves.

Conservation research in submarine caves is among the clearest and most compelling use-cases for a small observation-class ROV like Trident, which is why, last week, we delivered the very first ROV for Good Sofar Ocean Trident to Dr. Leocadio Blanco-Bercial at the Bermuda Institute of Ocean Sciences to study the hidden biodiversity in Bermuda’s Anchialine Caves.

Dr. Blanco-Bercial is a marine biologist who studies the diversity and evolution in invertebrates, especially those in marine cave ecosystems. Bermuda is home to a network of anchialine caves (caves connected to the sea through underwater passageways) which are home to a diverse array of rare and ancient arthropod lineages, many of which are unique to Bermuda. These species are under threat from land development and other human activities.

“From the science standpoint,” says Dr.  Blanco-Bercial, “the Trident will give us independence from specialized divers availability, and will simplify the logistics associated with the sampling process – the Trident is easy to carry even by a single person – and sampling attachments and other gear is easily transportable by another colleague.”

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Fun Science FRIEDay – The Emperor of all Maladies

The Emperor of all Maladies is how Siddhartha Mukherjee, an Indian-born American physician and oncologist, aptly described cancer. Cancer, this scourge of mankind going back as far as 4,600 years ago when it was identified by the Egyptian physician Imhotep (the first in recorded history). Cancer takes one of the most successful traits of complex eukaryotes, cell division, and weaponizes it in unchecked cellular growth; some even consider cancer to be a more evolved form of cell division. This ailment has plagued humanity, and baffled physicians for centuries as they attempt to tackle the seemingly impossible, discover a cure for cancer.

Scanning electron micrograph of a human T cell. (NIAID/Flickr/CC BY 2.0)
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We want to give you an ROV!

Sofar Ocean Trident
What will you explore?

If you have access to a small, observation-class remotely operated vehicle to explore the ocean, where would you go? Would you use it to discover something new about marine ecosystems? Would you give students the opportunity to journey beneath the waves and learn about their local waterways? Would you hunt for lost lobster traps, track ocean plastic, deliver sensor payloads down into the mesophotic zone, or identify and protect critical spawning habitats?

Or would you undertake an expedition so novel that it has yet to be conceived?

Conservation X Labs in collaboration with Schmidt Marine Technologies and Sofar Ocean is delivering 20 Sofar Ocean Trident ROVs to researchers (both formal and informal), educators, citizen scientists, and ocean conservationist to help further projects to study, understand, or protect the marine environment, with a broad focus on marine conservation. Grant recipients will receive a Trident ROV with all the fixings!

Sofar Ocean Trident represents the next-generation of underwater drone. It is an out-of-the-box solution for ocean stakeholders that can perform many of the same functions of major research ROVs for a fraction of the cost and with no specialized training. Small enough to be stored in carry-on baggage, the ROV is extremely portable and has been deployed from vessels ranging in size from small kayaks to ocean-class research vessels to Polynesian voyaging canoes. Trident is fast, with simple controls. It is rated to 100m. The vehicle provides live video footage to the pilot through a kevlar-reinforced tether which can also serve as a recovery line. It has a series of ventral M3 mounting points that allow users to affix a variety of sensors, collectors, and payloads to expand its utility. It is one of the few consumer accessible vehicles capable of performing scientific research, documentary observation, conservation monitoring, and exploration from the surface of the ocean down into the mesophotic zone.

The application is simple and streamlined to get you out exploring the ocean.

Apply today and let’s discover the ocean together!

The next generation of low-cost, open-source oceanographic instruments is here! Meet the OpenCTD rev 2!

Four generations of OpenCTD. Left to Right: Prototype 2, which went through sea trials in Lake Superior, rev 1, rev 1 in the smaller form factor (this one was deployed in Alaska), and OpenCTD rev 2.

In 2013, Kersey Sturdivant and I embarked upon a quixotic quest to create an open-source CTD — the core tool of all oceanographic research that measures the baseline parameters of salinity, temperature, and depth. We weren’t engineers; neither of us had any formal training in electronics or sensing. And, full confession, we weren’t (and still aren’t) even oceanographers! What we were were post-doc marine ecologists working with tight budgets who saw a desperate need among our peers and colleagues for low-cost alternatives to insurmountably expensive equipment. And we had ties to the growing Maker and DIY electronics movements: Kersey through his work developing Wormcam and me through my involvement with OpenROV. 

We had no idea what we were getting ourselves into. 

The very first OpenCTD prototype.

Seven years and five iterations later, we are releasing the long anticipated OpenCTD rev 2 as well as the comprehensive Construction and Operation Manual! OpenCTD rev 2 builds on over half a decade of iteration and testing, consultation with oceanographers, engineers, developers, and makers around the world, extensive coastal and sea trials, and a series of workshops designed to test and validate the assembly process. 

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Shark Week 2019 reviews and thoughts

I wasn’t able to watch live this year, but I DVR-ed all 18 specials and watched them eventually! Here are my reviews, ratings, and thoughts. I did not watch the feature-length movie, which they claim is the first fictional entertainment content they’ve ever produced… causing me to stare in megalodon. Overall, this was not a strong year for science, facts, or diversity (of either sharks or shark researchers).

As a reminder, I grade on the following aspects of a show: is there actual science or natural history educational content / is there made up nonsense, are actual credentialed experts with relevant expertise featured or are they self-proclaimed “shark experts” who say wrong nonsense all the time, what species are featured (with bonus points for species we rarely or never see), and do they feature diverse experts or just the same white men (reminder: my field is more than 50% women)? It’s not a perfect rubric, but it’s better than this actual system for ranking shark news introduced this year in “sharks gone wild 2:”

Rankings appear in no particular order, if you care about the order the shows actually aired in please see this Discovery press release.

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